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Effect of anti-CD30L mAb on spontaneous diabetes in NOD mice. Female NOD mice were injected i.p. with 500 µg RM153 (○, n = 10), RM153 F(ab/)2 (▵, n = 8), or control IgG (a) for 2–10 week of age (•, n = 7) or (b) 4–10 week of age (•, n= 11). Mice were monitored for development of diabetes until 30 week of age. *P < 0·0001 and †P < 0·02 versus control IgG group (a) and ‡P < 0·02 versus control IgG group (b) (Kaplan-Meier).
