Table 2.

Effect of anti-CD30L mAb in adoptive transfer experiments

	Control IgG		RM153
Donor	Diabetes	Insulitis	Diabetes	Insulitis
Diabetogenic splenocyte	10/16 (62%)	+ + +	4/16 (25%)*	+ + ∼ + + +
Islet-derived CD8 CTL	10/10 (100%)	+ + +	0/5 (0%)†	± ∼ +
YNK 7·3	0/4	+ + ∼ + + +	0/4	± ∼ +

Splenocytes from diabetic NOD mice (3 × 10⁷), islet-derived CD8⁺ CTL (1 × 10⁷), or YNK7·3 (1 × 10⁷) were i.p. injected into 7-day-old NOD-SCID mice. RM153 or control IgG (500 µg) were i.p. injected from one day before transfer and twice a week for three week after transfer. Pancreases from each group were removed at 8 week after transfer of with diabetic splenocytes, 7 d after transfer of CD8⁺ CTL, or 8 week after transfer of YNK7·3.

^*P < 0·05 versus control IgG

^†P < 0·001 versus control IgG group.