Table 1a.
Frequency, n (%), of reactivity to the HCV polyprotein and identified nuclear homologues in patients with chronic HCV infection, other chronic liver disorders and in normal healthy children
| Chronic HCV (n = 51) | Chronic HBV (n = 24) | ANA/SMA AIH (n = 12) | LKM1 AIH (n = 12) | ANA/SMA ASC (n = 12) | Wilson’s disease (n = 10) | Alagille’s syndrome (n = 11) | AATD (n = 11) | Healthy controls (n = 24) | |
|---|---|---|---|---|---|---|---|---|---|
| HCV-pol1479–1498 | 41 (80) | 2 (8) | 1 (8) | 3 (25) | 0 | 0 | 0 | 0 | 0 |
| Histone11–30 | 25 (49) | 2 (8) | 3 (25) | 0 | 3 (25) | 0 | 0 | 0 | 0 |
| HCV-pol1479–1498 and histone11–30 | 19 (37) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| HCV-pol743–762 | 20 (39) | 3 (12) | 1 (8) | 0 | 0 | 1 (10) | 0 | 0 | 0 |
| Matrin722–741 | 39 (76) | 13 (54) | 3 (25) | 1 (8) | 0 | 1 (10) | 0 | 1 (9) | 0 |
| HCV-pol743–762 and matrin722–741 | 17 (33) | 0 | 0 | 0 | 0 | 1 (10) | 0 | 0 | 0 |
| HCV-pol1859–1878 | 35 (69) | 4 (16) | 1 (8) | 4 (32) | 2 (17) | 0 | 0 | 1 (9) | 0 |
| Replication protein133–152 | 32 (63) | 3 (12) | 0 | 0 | 3 (25) | 0 | 0 | 0 | 0 |
| HCV-pol1859–1878 and replication protein133–152 | 20 (39) | 0 | 0 | 0 | 2 (17) | 0 | 0 | 0 | 0 |
n= number of patients; HCV = hepatitis C virus infection; HBV = hepatitis B virus infection; AIH = autoimmune hepatitis; ANA = anti nuclear antibody; SMA = smooth muscle antibody; LKM1 = liver kidney microsomal type 1 autoantibody; ASC = autoimmune sclerosing cholangitis; AATD = alpha 1 antitrypsin deficiency.