Table 1.

Engineered CD3 antibodies in clinical trials

Antibody	Construct	Phase	Indication	Reference
T3/4.A	Murine IgA	II	Kidney transplantation	[4]
YTH 12·5	Aglycosylated huIgG1	I	Kidney transplantation	[19]
HuM291	Mutated huIgG2	I	Kidney transplantation	[22]
		I	Bone marrow transplantation	[21]
hOKT3γ1[Ala-Ala]	Mutated huIgG1	I	Kidney transplantation	[26]
		I/II	Psoriasis arthritis	[27]
		II/III	Type I diabetes mellitus	[28]