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IFN-γ production by NK cells. (a) Flow cytometric profiles for intracellular IFN-γ expression in gated (left panel) NK cells from a healthy control donor and an HIV-1+ patient receiving HAART only with or without cytokine stimulation. (b) Both IL-2 + IL-12 and IL-15 + IL-12-induced NK cell IFN-γ expression are reduced significantly in 12 patients on HAART compared to healthy controls.
