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. 2004 Feb;135(2):209–218. doi: 10.1111/j.1365-2249.2003.02359.x

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© 2004 Blackwell Publishing Ltd

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Fig. 3 — DC from NOD mice produced low levels of IL-12p40. (A) Purified splenic CD11c⁺DC from untreated mice were cultured for 24 h with SAC/IFN-γ/GM. IL-12 p40 production was significantly lower in NOD than C57BL/6 or B10.BR DC (*P = 0·03 and P = 0·009, respectively). (b) IL-12p40 production by DCs following 24 h incubation with TNF-α (▪) or LPS/IFN-γ (). IL-12p40 was lower in NOD compared to C57BL/6 DC (*P = 0·04) following stimulation with TNF-α. No IL-12 p70 was detected. Results are presented as the mean of cytokine production ± SD of the indicated number of side-by-side experiments.

Inline graphic — DC from NOD mice produced low levels of IL-12p40. (A) Purified splenic CD11c⁺DC from untreated mice were cultured for 24 h with SAC/IFN-γ/GM. IL-12 p40 production was significantly lower in NOD than C57BL/6 or B10.BR DC (*P = 0·03 and P = 0·009, respectively). (b) IL-12p40 production by DCs following 24 h incubation with TNF-α (▪) or LPS/IFN-γ (). IL-12p40 was lower in NOD compared to C57BL/6 DC (*P = 0·04) following stimulation with TNF-α. No IL-12 p70 was detected. Results are presented as the mean of cytokine production ± SD of the indicated number of side-by-side experiments.