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DC subsets can modulate the development of diabetes in NOD mice. Ability of CD8+ (♦) and CD8− (○) splenic DC to modulate diabetes development in NOD mice. NOD mice (5 weeks of age; 10 mice/group) were given peptide-pulsed DC (4 × 105 DC/mouse iv) as described in the methods and were monitored for the development of diabetes. Control mice received an iv injection of PBS (▪). Results shown are from two independent experiments.
