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Effect of post-treatment of alveolar macrophages (AM) with PCT-233 and budesonide (BUD) on cytokine production. AM were stimulated with 10 ng/ml LPS for 18 h before being treated with PCT-233 and BUD (1 nm) alone or in combination and TNF (a) and IL-10 (b) were measured in cell-free supernatants. Control represents AM stimulated with LPS without other treatment. Data at day 0 correspond to cytokine levels just prior to PCT-233 and BUD treatment. Mean ± s.e.m. of six experiments.
