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. 2004 Mar;135(3):434–439. doi: 10.1111/j.1365-2249.2003.02370.x

Fig. 2.

Fig. 2

Somatostatin (SOM) inhibits chemokine (SDF-1α)-induced infiltration of T cells. Blood T lymphocytes were allowed to migrate into a collagen type I gel (>90% of the infiltrating cells were CD3+). SDF-1α (50 ng/ml) in the gel increased the infiltration depth of T lymphocytes (Fig. 1). This increase was inhibited significantly in the presence of somatostatin (10−8m) in the gel, while neuropeptide Y (NPY, 10−8m), metenkephalin (MET, 10−8m), β-endorphin (END, 10−8m), substance P (SP, 10−8m) and vasoactive intestinal peptide (VIP, 10−8m) in the gel had no effect on SDF-1α-induced infiltration. The figure shows mean maximal infiltration depth determined from three independent experiments and of 10 microscopic fields in each experiment (×100).