Fig. 2.

(a) Albuminuria in adriamycin-treated mice. Twenty-four-hour albumin excretion, measured by ELISA, was significantly increased 7 days after disease induction and persisted for 6 weeks after injection in adriamycin-treated mice (n = 8). Values are expressed as means ± SD. *P < 0·01 compared to control mice. • adriamycin-treated group; ○ control group. (b) Renal histology. PAS stained section of mice sacrificed 6 weeks after adriamycin injection. Glomeruli of adriamycin-treated mice showed mesangial matrix expansion and glomerular sclerosis (arrows) and tubular dilatation and cast formation (*). Renal morphology of saline-injected, control mice is shown for comparison (c). Magnification (b, c × 200).