Table 3.
Reinduction of EAE in DA rats previously immunized with RSCH-PBS
| I immunizationa | II immunizationa | |||||
|---|---|---|---|---|---|---|
| Exp.no. | Maximal Incidenceb | Onsetc | scored | Maximal Incidenceb | Onsetc | scored |
| 1 | 9/9 | 14·7 ± 2·1 | 1·6 ± 0·9 | 9/9 | 10·8 ± 0·9 | 2·8 ± 0·6* |
| – | – | – | 13/13 | 12·2 ± 3·2 | 3·8 ± 0·4 | |
| 2 | 3/3 | 8·3 ± 0·9 | 2·7 ± 0·9 | 3/3 | 12·3 ± 0·9 | 2·5 ± 0·9 |
| – | – | – | 4/4 | 11·0 ± 4·2 | 3·5 ± 2·2 | |
| 3 | 7/7 | 10·4 ± 5·3 | 2·5 ± 2·1 | 7/7 | 9·0 ± 7·7 | 1·2 ± 1·6* |
| – | – | – | 4/4 | 12·0 ± 2·8 | 3·0 ± 0·0 | |
a
Rats were immunized with RSCH-PBS (I immunization) and 30–35 days later with RSCH-CFA (II immunization)
b
number of rats with clinical signs of EAE/total number of rats
c
mean day ± s.d. when first signs of EAE appeared
d
mean maximal clinical score ± s.d. in diseased rats
*
statistically significant by Student's t-test (P < 0·001) versus corresponding control group of rats.