Table 1.

Histology of foot sections of I-316 PSGL-1 treated mice as compared to vehicle treated mice

Arthritic changes	Control treated (n = 12)	I-316 PSGL-1 treated (n = 12)
Normal	16% (2/12)	34% (4/12)*
Mild	34% (4/12)	50% (6/12)*
Moderate	25% (3/12)	8% (1/12)*
Severe	25% (3/12)	8% (1/12)*

Histological findings at the end of the 10-day treatment period in CIA with I-316 PSGL-1 (six mice in group) and PBS as the control treated group (six mice in group). Arthritic joint changes were scored by an observer blinded to the treatments received; and were graded as normal, mild, moderate or severe changes to the degree of destruction of the joint architecture. The results are shown as the percentage of all arthritic feet studied (n = 12) that were graded as a specific histology score as outlined in Materials and Methods.

^*P = 0·0171 (χ² test) when arthritic changes of normal and mild were compared to moderate and severe amongst control versus I-316 PSGL-1 treated mice.