Table 2.

Histology of foot and knee sections of rPSGL-1Ig fusion protein treated mice as compared to vehicle treated mice

Arthritic changes	Control treated (n = 20)	rPSGL-1Ig treated (n = 18)
Foot sections
Normal	10% (2/20)	28% (5/18)
Mild	5% (1/20)	22% (4/18)
Moderate	5% (1/20)	39% (7/18)
Severe	80% (16/20)	11% (2/18)*
Knee sections
Normal	5% (1/20)	45% (8/18)†*
Mild	10% (2/20)	5% (1/18)†
Moderate	50% (10/20)	28% (5/18)†
Severe	35% (7/20)	22% (4/18)†*

Histological findings at the end of the 10-day treatment period in CIA with rPSGL-1Ig fusion protein. Arthritic changes to the knee joint or foot were scored by an observer blinded to the treatments received; and were graded as normal, mild, moderate or severe changes to the degree of destruction of the joint architecture. The results are shown as the percentage of all arthritic knees or feet studied (n = 20 or 18).

^*P = 0·0171 (χ² test) when arthritic changes of normal, mild and moderate were compared to severe changes of feet amongst control versus rPSGL-1Ig treated mice. Arthritic changes of normal and mild were compared to moderate and severe changes of knees amongst control versus rPSGL-1Ig treated mice

^†(P = 0·0205), while normal versus severe changes amongst the two treatment groups had a ^*P-value of 0·0171 by the χ² test.