Table 1.

Effects of itraconazole on the net efflux of ⁴⁵Ca²⁺ from neutrophils activated with FMLP or PAF

System	Net efflux of 45Ca2+ (pmol/107 cells/60 s)
FMLP (1 µm)	185·9 ± 24·0
Itraconazole (5 µm) + FMLP (1 µm)	152·6 ± 17·8**
PAF (200 nm)	158·5 ± 7·1
Itraconazole (5 µm) + PAF (200 nm)	133·3 ± 8·0*

The results are expressed as the mean values ±s.e.m. of 4 different experiments with 5 replicates in each.

^*P < 0·001;

^**P < 0·04 for comparison with the corresponding itraconazole-free system.