Table 3.
Effects of itraconazole on inositol triphosphate (IP3) in neutrophils activated with FMLP or PAF
| IP3 concentration (pmol/107 cells) | ||
|---|---|---|
| System | 5 s | 10 s |
| Control | 62·4 ± 4·2 | ND |
| Itraconazole (5 µm) | 65·3 ± 0·8 | ND |
| FMLP (1 µm) | 87·8 ± 2·6* | 85·8 ± 2·0* |
| Itraconazole (5 µm) + FMLP (1 µm) | 101·1 ± 6·2 | 78·7 ± 6·2 |
| PAF (200 nm) | 112·2 ± fn1·7* | 70·3 ± 8·4 |
| Itraconazole (5 µm) + PAF (200 nm) | 99·7 ± 2·0 | 87·6 ± 5·0 |
The results are expressed as the mean values±s.e.m. of 4 determinations.
*
P ≤ 0·003 for comparison with the corresponding itraconazole-free system. ND, not done.