Table 2.
Frequencies of cell surface and intracellular markers in CD4+CD25+, CD4+CD25− and CD4+CD25+CTLA-4i+ subsets of mononuclear cells from term decidua (n = 5–7) and peripheral blood from nonpregnant controls (n = 5)
| CTLA-4 s | CTLA-4i | CD69 | CD40L | OX40 | GITR | |
|---|---|---|---|---|---|---|
| Decidual | ||||||
| CD4+CD25+ | 8·3 ± 6·6** | 48 ± 26** | 46 ± 19** | 2·0 ± 3·2 | 12 ± 10 | 48 ± 11** |
| CD4+CD25− | 1·8 ± 2·3 | 8·5 ± 7·4* | 68 ± 10** | 6·4 ± 6·7 | 5·2 ± 2·1* | 27 ± 10** |
| CD4+CD25+CTLA-4i+ | 70 ± 11** | 0·8 ± 0·8 | 65 ± 12** | 86 ± 7·5** | ||
| Control PB | ||||||
| CD4+CD25+ | 1·7 ± 2·2 | 7·6 ± 3·8 | 3·0 ± 1·5 | 0·9 ± 1·3 | 5·8 ± 3·3 | 1·2 ± 1·9 |
| CD4+CD25− | 0·5 ± 0·8 | 1·1 ± 0·8 | 3·5 ± 3·1 | 1·5 ± 1·8 | 2·2 ± 1·2 | 0·3 ± 0·3 |
| CD4+CD25+CTLA-4i+ | 3·5 ± 3·0 | 3·1 ± 3·8 | 7·9 ± 8·7 | 4·5 ± 4·5 | ||
Cell surface expression of CTLA-4 (CTLA-4 s), Intracellular expression of CTLA-4 (CTLA-4i).
**
P < 0·01,
*
P < 0·05, when compared with the same population from PB.