Table 3.

EV titre (log₁₀ TCID₅₀/ml) in blood of BALB/c mice infected with EV, strain K-1, at a dose of 5 LD₅₀ and treated by different schemes

	Day post-infection
Group	7	9	11	21
A2	5·2 ± 0·2	6·2 ± 0·4	6·5 ± 0·4	6·8 ± 0·4	–
B2	5·1 ± 0·2	5·6 ± 0·2*	5·2 ± 0·2	4·6 ± 0·2**	0
C2	5·0 ± 0·1	5·8 ± 0·2*	5·6 ± 0·2	5·2 ± 0·2	0
D2	5·2 ± 0·1	5·6 ± 0·2*	5·2 ± 0·2	4·7 ± 0·2**	0

^*Statistically significant difference with the maximum in the control A2 group (P < 0·01).

^**Statistically significant difference with group C2 on day 11 (P < 0·05). Mice were treated by different schemes of rmTNF-αand rmIFN-γ (see Table 1).