Table 3.

Histological findings of skin lesion in examined mice

Mice	Treatment	Hyperkeratosis	Plugging	Acanthosis	Liquefaction degeneration	Mononuclear cell infiltration
C57BL/6 J	1 PBS	0	0	0	0	0
	2 Low FU (1 mg/ml)	10	10	20	0	10
	3 High FU (10 mg/ml)	17	25	8	8	67
	4 UVBL (200 mJ/cm2)	82	45	82	18	73
	5 Low FU plus UVBL	100	67	33	33	100
	6 High FU plus UVBL	80	100	80	60	80
TCR-α–/–mice	1 PBS	0	0	0	0	0
	2 Low FU (1 mg/ml)	67	50	0	0	83
	3 High FU (10 mg/ml)	n.d.	n.d.	n.d.	n.d.	n.d.
	4 UVBL (200 mJ/cm2)	100	67	50	17	67
	5 Low FU plus UVBL	100	100	78	44	100
	6 High FU plus UVBL	n.d.	n.d.	n.d.	n.d.	n.d.
TCR-δ–/– mice	1 PBS	17	0	17	0	50
	2 Low FU (1 mg/ml)	0	67	67	17	83
	3 High FU (10 mg/ml)	n.d.	n.d.	n.d	n.d.	n.d.
	4 UVBL (200 mJ/cm2)	42	42	58	25	83
	5 Low FU plus UVBL	67	75	100	58	92
	6 High FU plus UVBL	n.d.	n.d.	n.d.	n.d.	n.d.

Specimens were obtained from the back of killed and/or autopsied mice and stained with haematoxylin eosin solution. Each figure represents the percentage (%). n.d.: Data were excluded because of high mortality. Five to 14 mice were examined in each treatment.