Table 6.
Anti-DNA antibodies (Ig G) in sera of examined mice
| C57BL/6 J | TCR-α–/– | TCR-δ–/– | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Group | No. examined | dsDNA | ssDNA | No. examined | dsDNA | ssDNA | No. examined | dsDNA | ssDNA |
| 1 PBS | (6) | <0·05 | <0·05 | (6) | <0·05 | <0·05 | (6) | <0·05 | <0·05 |
| 2 Low FU (1 mg/ml) | (7) | <0·05 | <0·05 | (8) | <0·05 | <0·05 | (6) | <0·05 | <0·05 |
| 3 High FU (10 mg/ml) | (10) | <0·05 | <0·05 | (0) | n.d. | n.d. | (0) | n.d. | n.d. |
| 4 UVBL (200 mJ/cm2) | (10) | <0·05 | 0·11 (0·07) | (6) | <0·05 | 0·21 (0·11) | (8) | <0·05 | 0·17 (0·09) |
| 5 Low FU plus UVBL | (6) | <0·05 | 0·07 (0·14) | (8) | <0·05 | 0·18 (0·09) | (11) | <0·05 | 0·16 (0·15) |
| 6 High FU plus UVBL | (5) | <0·05 | <0·05 | (0) | n.d. | n.d. | (0) | n.d. | n.d. |
n.d.: Data were excluded because of high mortality. The levels of anti-DNA antibodies are expressed as the mean values of the optical density (standard deviation). Positive controls (pooled sera form aged MRL/lpr mice) showed 0·24 (0·09) for antidsDNA antibody and 1·29 (0·43) for antissDNA antibody.