Table 5.
Macrophage genes differentially expressed after infection with pathogenic and non-pathogenic mycobacteria
| M. tuberculosis Fold induction at time point (h) | M. avium Fold induction at time point (h) | M. smegmatis Fold induction at time point (h) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Gene Bank ID | Function | 4 | 12 | 24 | 4 | 12 | 24 | 4 | 12 | 24 |
| ERBB3 | M29366 | Signal transduction/adhesion | – | – | 3·5 | 3 | 6·7 | 4·8 | – | – | 4 |
| ICAM1 | J03132 | Signal transduction/adhesion | – | – | – | – | – | 3·7 | – | 3 | 5·2 |
| NDUFB7 | M33374 | Adhesion | – | −4 | – | – | – | – | – | 5·2 | – |
| IL1B | K02770 | Cytokine | – | 3·3 | 4 | – | 3 | 3·8 | – | 3 | 3·7 |
| GROB(MIP2) | X53799 | Cytokine | 3 | 5 | 3 | – | 2·7 | 8·7 | 3·5 | 4·5 | 16·8 |
| TNFA | X01394 | Cytokine | – | 3 | 2 | – | 5·2 | 3·8 | 4 | 8 | 5·8 |
| RANTES | M21121 | Cytokine | – | 6·8 | – | – | 4·7 | 3 | – | 4·5 | 3 |
| SSP1 | X13694 | Cytokine | 2 | 3 | – | – | – | – | – | – | 4·5 |
| IL2RG | D11086 | Cytokine receptor | – | 3 | – | – | 4·3 | – | – | 3·2 | – |
| IL8 | Y00787 | Chemokine | – | – | 3 | – | – | 4 | – | 3 | 8·3 |
| Neuroleukin | K03515 | Lymphokine | – | 4·1 | – | – | 3·5 | – | – | 5·9 | 3 |
| GNB2L1 | M24194 | G protein | 2·3 | 3 | – | – | 3·4 | – | 3·1 | 4·5 | 2·9 |
| GNB1 | M36430 | G protein | – | – | 4·4 | – | 3·5 | 10 | – | 3 | 12·5 |
| CDKN1A | U09579 | Kinase inhibitor/cell cycle | – | – | – | – | 4·1 | – | 3·6 | 3·4 | – |
| JUN | J04111 | Transcription factor | – | – | – | – | 4 | – | 3 | 5·9 | 3·7 |
| MMP9 | J05070 | Metalloproteinase | – | 4·4 | – | – | 5 | – | – | 5 | 4·5 |
| FGF11 | U66199 | Growth factor | 3 | 3 | 5 | 3·4 | 3·7 | – | 2·5 | 3·1 | 5 |
| IEX-L1 | AF039067 | Apoptosis | – | 4 | – | – | 5·9 | 3·1 | 3 | 4 | – |