Table 2.
Prevalence of autoantibody to parietal cells in neonatal thymectomized BALB/c mice administered with poly I:C
| Prevalence of parietal cell autoantibodies | ||||
|---|---|---|---|---|
| Neonatal thymectomy | Administration of poly I:C | Number | Parietal cell antibodies + ve | % |
| + | None | 12 | 6 | 50·0 |
| + | 1st week | 12 | 10 | 83·3 |
| + | 2nd week | 14 | 12 | 85·7 |
| + | 1st and 2nd weeks | 11 | 9 | 81·8 |
| + | 3rd week | 10 | 5 | 50·0 |
| + | 3rd and 4th weeks | 10 | 5 | 50·0 |
| + | 1st- 4th weeks | 21 | 21 | 100·0 |
| – | 1st- 4th weeks | 10 | 0 | 0 |
BALB/c mice were thymectomized on day 3 after birth. These thymectomized mice were either administered with poly I:C or PBS. Poly I:C was administered twice in a week, as described in Table. 1. The presence of autoantibody to parietal cell was estimated by indirect immunofluorescence.