Table 4.
Increased levels of proinflammatory cytokines in neonatal thymectomized mice treated with poly I:C
| n | IL-10 (pg/ml) | IL-6 (pg/ml) | MCP-1 (pg/ml) | IFN-γ (pg/ml) | TNF-α (pg/ml) | IL-12p70 (pg/ml) | |
|---|---|---|---|---|---|---|---|
| (a)Poly I:C-treated thymectomized | 3 | 36·5 ± 12·6 | 368·3 ± 115·4* | 303·5 ± 61·9* | 25·8 ± 9·0* | 72·5 ± 14·5* | 268·6 ± 121·9* |
| (b)Poly I:C-treated nonthymectomized | 3 | 33·7 ± 9·2 | 250·1 ± 115·2* | 200·6 ± 49·0* | 19·8 ± 2·0* | 59·1 ± 16·0* | 165·5 ± 92·6* |
| (c)PBS-treated thymectomized | 3 | 17·0 ± 10·2 | 143·1 ± 86·0 | 96·7 ± 33·8 | 10·0 ± 6·2 | 33·5 ± 14·1 | 56·4 ± 25·2 |
BALB/c mice were thymectomized on day 3 after birth (a, c) or remained untreated (b). Neonatal thymectomized mice received either poly I:C (a) or PBS (c), twice in a week for 4 consecutive weeks. Non-thymectomized mice received poly I:C (b). All mice were killed 4 weeks after thymectomy or poly I:C administration. The levels of cytokines in the sera were estimated by CBA method.
*
P < 0·05 compared to PBS-treated thymectomized mice.