Fig. 4.

Effect of anti5H9 on T cell proliferation induced by recombinant beta₂-GPI and TT. (a) The effect on proliferative response to recombinant beta₂-GPI (5 µg/ml) (left panel) and TT (5 ng/ml) (right panel) was assessed with various concentrations of MoAb, isotype-matched control MoAb (anti4B4), anti5H9 and anti-HLA DR MoAb (anti-L243). Data are expressed as mean cpm ± s.d. of triplicate samples. Representative data of three independent experiments are shown. *Significant inhibition compared to the culture with isotype-matched control MoAb (P < 0·05). (b) Inhibitory effect of anti5H9 (15 µg/ml) on beta₂-GPI-induced T cell proliferation was compared with those of various MoAbs (15 µg/ml). Data are expressed as mean cpm ± s.d. of sextuple samples. Representative data of three independent experiments are shown. *Significant inhibition compared to the culture without MoAb (P < 0·05).