Table 2.
Estimated haplotype frequencies of the IL-1 genotypes from a normal control population
| Loci | Haplotype | |||||||
|---|---|---|---|---|---|---|---|---|
| 1–1 | 1–2 | 2–1 | 2–2 | 1–3,4,5,6 | 2–3,4,5,6 | χ2 | P | |
| IL1A−889/IL1A VNTR | 0·352 | 0·198 | 0·239 | 0·009 | 0·173 | 0·027 | 36·45 | <0·0001 |
| IL1A−889/IL1B−511 | 0·428 | 0·3 | 0·187 | 0·085 | 4·72 | 0·316 | ||
| IL1A−889/IL1B +3954 | 0·66 | 0·064 | 0·089 | 0·187 | 117·5 | <0·0001 | ||
| IL1A−889/IL1RN VNTR | 0·531 | 0·17 | 0·212 | 0·061 | 0·026 | <0·001 | 3·227 | 0·5214 |
| IL1B−511/IL1A VNTR | 0·472 | 0·073 | 0·120 | 0·134 | 0·077 | 0·125 | 66·6 | <0·0001 |
| IL1B−511/IL1B +3954 | 0·421 | 0·196 | 0·329 | 0·053 | 11·87 | 0·0183 | ||
| IL1B−511/IL1RN VNTR | 0·506 | 0·094 | 0·231 | 0·142 | 0·016 | 0·01 | 20·45 | 0·0004 |
| IL1B +3954/IL1A VNTR* | 0·35 | 0·201 | 0·245 | <0·001 | 0·192 | 0·012 | 55·69 | <0·0001 |
| IL1B +3954/IL1RN VNTR | 0·516 | 0·207 | 0·220 | 0·031 | 0·027 | <0·001 | 9·35 | 0·0529 |
| IL1A VNTR/IL1RN VNTR | 0·463 | 0·121 | 0·147 | 0·06 | 0·007 | |||
P-values indicate significance of association where loci can be demonstrated to be linked, the specific alleles that are linked together are illustrated by higher frequency values as described in the text.
*
These polymorphic loci are not listed in order across the locus to aid the clarity of the table.