Table 1.
Plasma cytokine levels (pg/ml) for patient and control groups
| Name | ID | CAT | Weeks | Days | Th1/Th2 CBA kit | Inflammatory CBA kit | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-γ | TNF-α | IL-10 | IL-5 | IL-4 | IL-2 | IL-12 | TNF-α | IL-10 | IL-6 | IL-1b | IL-8 | |||||
| P1 | 57 | c-staph | 1 | 2 | 0 | 0 | 1·2 | 1·5 | 0 | 0 | 0 | 0 | 1·6 | 0 | 2·1 | 14·6 |
| P2 | 58 | gbs | 1 | 3 | 0 | 1·4 | 1·8 | 2·2 | 1·5 | 1·4† | 21·6 | 11 | 7·1 | 0 | 89·5 | 57·5 |
| P3 | 59 | serrati | 1 | 2 | 0 | 0 | 8·4 | 7·5 | 0 | 0 | 8·7 | 0 | 26 | 9·9 | 19·4 | 380 |
| P4 | 60 | s.aure | 1 | 5 | 723 | 3·5 | 13·5 | 2·1 | 0 | 0 | 24·7 | 7·8 | 27·2 | 3080 | 0 | 861 |
| P5 | 61 | kleb | 1 | 1 | 10·3 | 8·9 | 4313·8 | 1·9 | 0 | 0 | 12·7 | 13·1 | 4763 | 4270 | 30 | 529 |
| P6 | 63 | candid | 1 | 3 | 30 | 0 | 10·9 | 0 | 0 | 0 | 31·9 | 1·9 | 33·8 | 66·4 | 36·3 | 122 |
| C1 | 62 | c | 1 | 7 | 0 | 0 | 2·1 | 1·3 | 0 | 0 | 9·6 | 0 | 7·6 | 0 | 11·5 | 47 |
| C2 | 64 | c | 1 | 5 | 1·7 | 0 | 2·5 | 1·8 | 1·2 | 0 | 0 | 0 | 7·8 | 0 | 16·4 | 73 |
| C3 | 65 | c | 1 | 4 | 4·9 | 1·5 | 2·4 | 2·1 | 1·5 | 0 | 0 | 2·6 | 2·9 | 0 | 6·5 | 67 |
| C4 | 66 | c | 1 | 6 | 2·6 | 0 | 2·3 | 1·6 | 0 | 0 | 0 | 1·5 | 3·6 | 0 | 0 | 26 |
| C5 | 67 | c | 1 | 2 | 1·2 | 1 | 1·6 | 6·7 | 1·3 | 0 | 0 | 0 | 0 | 34·1 | 10·2 | 95 |
| C6 | 68 | c | 1 | 6 | 1·7 | 1·4 | 1·4 | 1·8 | 1·2 | 0 | 0 | 0 | 0 | 0 | 0 | 54 |
| *Mean | 4·8 | 2·0 | 0·5 | 2·0 | 2·5 | 0·9 | 0 | 1·6 | 0·7 | 3·6 | 5·7 | 7·4 | 60·3 | |||
| s.d. | 1·79 | 1·65 | 0·73 | 0·45 | 2·05 | 0·70 | 0 | 3·9 | 1·10 | 3·46 | 13·92 | 6·57 | 23·68 | |||
| Range | 1–7·4 | 0–5·5 | 0–2·9 | 1·7–3·5 | 0–6·6 | 0–2·3 | >0 | 0–9·6 | 0–2·9 | 0–11 | 0–32 | 0–21 | 13–108 | |||
| P7 | 69 | c-staph | 2 | 8 | 16·4 | 0 | 3·7 | 19 | 1·1 | 3·3 | 0 | 0 | 7·2 | 0 | 13·4 | 80 |
| P8 | 70 | c-staph | 2 | 10 | 2·4 | 1·4 | 4·3 | 18·5 | 0 | 0 | 0 | 0 | 6·5 | 182 | 0 | 360 |
| P9 | 71 | ecoli | 2 | 8 | 1·9 | 0 | 0 | 3·8 | 0 | 0 | 20·2 | 0 | 0 | 0 | 45·7 | 62 |
| P10 | 72 | c-staph | 2 | 10 | 0 | 1·2 | 497·3 | 1·7 | 0 | 0 | 0 | 0 | 425 | 0 | 29 | 0 |
| P11 | 73 | mycop | 2 | 9 | 0 | 0 | 1·6 | 0 | 0 | 0 | 0 | 0 | 10·4 | 0 | 8·1 | 45 |
| P12 | 74 | candid | 2 | 11 | 8·3 | 1·8 | 70·6 | 0 | 0 | 0 | 0 | 5·8 | 243 | 100 | 14·6 | 3594 |
| C7 | 75 | c | 2 | 9 | 0 | 0 | 1·8 | 4·5 | 0 | 0 | 0 | 0 | 5·2 | 0 | 4·2 | 62 |
| C8 | 86 | c | 3 | 13 | 6·4 | 0 | 5·9 | 2·8 | 0 | 0 | 0 | 0 | 14 | 23·7 | 7 | 106 |
| C9 | 77 | c | 2 | 10 | 0 | 0 | 2 | 1·7 | 1·9 | 1·2 | 0 | 0 | 0 | 0 | 0 | 22 |
| C10 | 89 | c | 2 | 14 | 5·5 | 0 | 1·4 | 0 | 2·2 | 0 | 0 | 0 | 9 | 22·8 | 0 | 96 |
| C11 | 79 | c | 2 | 13 | 0 | 1·3 | 0 | 0 | 1·6 | 0 | 0 | 2·9 | 4 | 5·4 | 17 | 129 |
| C12 | 80 | c | 2 | 9 | 0 | 0 | 2·6 | 4 | 1·2 | 1·4 | 0 | 5·8 | 8 | 0 | 13 | 61 |
| *Mean | 11·3 | 2·0 | 0·2 | 2·3 | 2·2 | 1·1 | 0·4 | 0 | 1·4 | 6·7 | 8·6 | 6·9 | 79·3 | |||
| s.d. | 2·25 | 3·08 | 0·53 | 1·97 | 1·94 | 0·95 | 0·70 | 0 | 2·43 | 4·79 | 11·50 | 6·95 | 38·41 | |||
| Range | 7–16·1 | 0–8 | 0–1·2 | 0–6·3 | 0–6 | 0–3 | 0–1·7 | >0 | 0–6·3 | 0–16 | 0–32 | 0–20 | 2–156 | |||
| P13 | 81 | candid | 3 | 17 | 0 | 0 | 2·1 | 0 | 0 | 0 | 141 | 0 | 0 | 16 | 155 | 97 |
| P14 | 82 | candid | 3 | 16 | 0 | 0 | 2·6 | 5·1 | 1·7 | 0 | 0 | 0 | 9·5 | 0 | 12·1 | 162 |
| P15 | 84 | c-staph | 3 | 15 | 251·7 | 1·9 | 188·1 | 0 | 0 | 1·1 | 0 | 4·5 | 325 | 167·3 | 4·2 | 105 |
| P16 | 85 | gbs | 3 | 19 | 9 | 2·2 | 4·2 | 1·3 | 1·2 | 2·3 | 0 | 9·7 | 0 | 15 | 67·8 | 150 |
| P17 | 76 | unident | 3 | 18 | 19 | 0 | 13·8 | 1·9 | 1·2 | 0 | 8·5 | 1·4 | 34·8 | 39·7 | 23 | 78 |
| P18 | 78 | unident | 3 | 16 | 2·7 | 0 | 12·4 | 7 | 1·2 | 0 | 4·3 | 0 | 35 | 64·4 | 14·5 | 186 |
| C13 | 83 | c | 3 | 20 | 3·7 | 0 | 1·9 | 1·7 | 1·1 | 0 | 0 | 0 | 0 | 26·5 | 0 | 142 |
| C14 | 86 | c | 3 | 16 | 6·4 | 0 | 5·9 | 2·8 | 0 | 0 | 0 | 0 | 14 | 23·7 | 7 | 106 |
| C15 | 87 | c | 3 | 19 | 0 | 0 | 0 | 1·1 | 0 | 0 | 0 | 3·4 | 5 | 0 | 13·4 | 38 |
| C16 | 88 | c | 3 | 17 | 0 | 1·1 | 3·2 | 3·6 | 0 | 0 | 0 | 2·4 | 13 | 0 | 11·4 | 136 |
| C17 | 89 | c | 3 | 15 | 5·5 | 0 | 1·4 | 0 | 2·2 | 0 | 0 | 0 | 9 | 22·8 | 0 | 96 |
| C18 | 90 | c | 3 | 18 | 2·6 | 0 | 0 | 2·7 | 0 | 0 | 0 | 0 | 6 | 0 | 17 | 12 |
| *Mean | 17·5 | 3·0 | 0·2 | 2·1 | 2·0 | 0·6 | 0 | 0 | 0·9 | 7·8 | 12·1 | 8·1 | 88·3 | |||
| s.d. | 1·87 | 2·70 | 0·44 | 2·23 | 1·31 | 0·92 | 0 | 0 | 1·53 | 5·27 | 13·38 | 7·08 | 52·69 | |||
| Range | 14–21 | 0–8·4 | 0–1 | 0–6·4 | 0–3·6 | 0–2·4 | >0 | >0 | 0–4 | 0–18 | 0–39 | 0–22 | 0–193 | |||
Gbs, group B streptococcus: s.aureus, Staphylococcus aureus: c-staph, coagulase negative staphylococcus: ecoli, Escherichia coli: ser, Serratia marscecens: klebs, Klebsiella: mycoplas, Mycoplasma pneumoniae: unident, unidentified organisms.
*
Mean, standard deviation and range for cytokine levels for control groups aged 0–7, 8–14 and 15–21 days.
†
Bold type indicates significantly increased level of cytokine in infected group compared to control group. C (control), P (patient).