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Proximal human IL-12 p40 promoter constructs. (a) Schematic representation of putative transcription factor binding sites and their location within the proximal human IL-12 p40 promoter. Adapted from X. Ma et al. (1996) Temp. Journal of Experimental Medicine 183: 147–157. (b) Schematic representation of NF-κB, AP-1, and Sp1 IL-12 p40 promoter mutants in the context of a luciferase reporter construct, relative to the wild-type promoter.
