Fig. 2.

Epitopes bound by PR3–ANCA in a three-dimensional model of PR3. Three-dimensional model of PR3 according to the coordinates provided by Fujinaga et al. [41]. Amino acids are numbered in agreement with the PR3 sequence published by Campanelli et al. [76]. α-Helixes are shown in coiles and the Β sheets are shown as arrows. The amino acids His44, Asp91 and Ser176 form the catalytic triad of PR3. Epitope regions of Fig. 1b are given; first epitopic region (dots), second region (stripes), third region (stripe-dot strip), fourth region (long lines) and fifth region (heavy line).