Table 5.
Summary of changes in TREC values, and percentages and absolute counts of CD4+ T cell subsets in HIV-infected children after 1 year on HAART according to virological response
| Characteristics | VL = 400 copies/ml | VL > 400 copies/ml | P |
|---|---|---|---|
| No. children | 7 | 7 | |
| Age (years) | 1 (0·9; 1·0) | 0·9 (0·8; 1·3) | 0·710 |
| TREC | 4636 (−5022; 15719) | 852 (376; 11610) | 0·530 |
| CD4+ T cell subsets (%) | |||
| CD4+ | 10·6 (3·5; 27·6) | 3·7 (−2·5; 14·5) | 0·026 |
| CD4+ CD45RA+ CD62L+ | 20·9 (3·3; 63·1) | 6·5 (−10; 17·3) | 0·073 |
| CD4+ CD45RO+ | −6·3 (73·6; 1·9) | −0·3 (−9·9; 8·70) | 0·097 |
| CD4+ HLA-DR-CD38+ | 3·1 (−5·0; 52·8) | −1·5 (−20·6; 6·1) | 0·097 |
| CD4+ CD38+ | 10·5 (− 1·8; 38·5) | 2·8 (−10·2; 13·1) | 0·105 |
| CD4+ T cell subsets (cells/mm3) | |||
| CD4+ | 364 (62; 764) | 109 (57; 518) | 0·073 |
| CD4+ CD45RA+ CD62L+ | 392 (56; 600) | 98 (12; 367) | 0·026 |
| CD4+ CD45RO+ | 144 (14; 265) | 47 (35; 136) | 0·053 |
| CD4+ HLA-DR-CD38+ | 325 (41; 694) | 62 (−3·2; 378) | 0·038 |
| CD4+ CD38+ | 384 (38; 709) | 88 (29; 431) | 0·053 |
VL: viral load. TREC: TCR rearrangement excision circles. Values are expressed as median (min, max). P: level of significance.