Fig. 5.

Lymphocyte proliferation in 9 normal adults (▿) and CVID patients (▵). (a) PBMC were incubated with antigens directly or (b) purified T cells with MdDC-col pulsed for 48 h with antigens. T cell incorporation of tritiated thymidine (cpm) for 18 h was measured in triplicate after culture of cells for 7 days; maximum uptake on concentration curve shown for each antigen. Stimulation index (SI) was derived by dividing cpm values by the basal proliferation rate of unstimlated PBMC or unpulsed dendritic cells. Where results are similar in different individuals, only one triangle is shown. Comparisons made using Mann–Whitney U-test.