Table 2.
Synthesis of cytokines in diabetic mice.*
| IL-12† | IFN-γ† | IL-4† | |
|---|---|---|---|
| Lung | |||
| CNT | 531 ± 245 | 11008 ± 8141 | 462 ± 62 |
| DM | 201 ± 105§ | 6015 ± 2482‡ | 736 ± 338‡ |
| DM/insulin | 418 ± 166** | 8899 ± 2697¶ | 575 ± 93¶ |
| Liver | |||
| CNT | 1025 ± 476 | 14263 ± 2392 | 997 ± 252 |
| DM | 728 ± 333‡ | 9307 ± 1363§ | 1995 ± 663§ |
| DM/insulin | 1190 ± 345¶ | 11209 ± 1664¶ | 1791 ± 734¶ |
| Spleen | |||
| CNT | 457 ± 222 | 7283 ± 2127 | 568 ± 107 |
| DM | 230 ± 49§ | 5355 ± 520§ | 533 ± 164‡ |
| DM/insulin | 497 ± 124** | 6462 ± 1017¶ | 480 ± 76¶ |
*
Diabetic(DM) or Control (CNT) mice were infected with M. tuberculosis and DM mice received treatment with insulin. The concentrations of the cytokines in lung, liver and spleen on day 14 were measured.
†
Mean ± SD (pg/organ) of 5 to 6 mice.
‡
Not significant compared with CNT mice.
§
P < 0.05 compared with CNT mice.
¶
Not significant compared with DM mice.
**
P < 0.05 compared with DM mice.