Fig. 1.

CCR7 is expressed on epithelium of non-inflamed gastric mucosa (a), H. pylori gastritis (b), intestinal metaplasia (e), dysplasia (f) and gastric carcinoma (g,h) as shown by immunohistochemistry. CCR7 control staining was negative, as shown clearly in non-inflamed gastric mucosa (c) and H. pylori gastritis (d). Epithelium of H. pylori gastritis, intestinal metaplasia, dysplasia and gastric carcinoma clearly expressed CCR7 stronger than the epithelium of non-inflamed gastric mucosa, suggesting that CCR7 is up-regulated during carcinogenesis. Original magnification: a–h ×400.