Fig. 2.

Estren affects thymus cellularity via ER-independent pathways. Thymus cellularity in 11-month-old OVX WT and DERKO mice is presented. The mice were given daily s.c. injections of 0·7 µg E2/mouse or 75 µg estren/mouse during 4 weeks. Control mice received vehicle olive oil. Treatment with E2 results in reduced thymus cellularity in WT mice but not in DERKO mice, while treatment with estren results in lower thymus cellularity also in DERKO mice. One-way anova followed by Fisher's exact test was used to compare data from control mice with E2 or estren-treated mice. *P < 0·05, **P < 0·01, ***P < 0·001. Results are presented as mean ± standard deviation. n = 5–8 mice in each group.