Fig. 5.

Estren inhibits the level of IL-6 in serum through ERs. The levels of IL-6 in serum (pg/ml) of 11-month-old OVX WT and DERKO mice are presented. The mice were given daily s.c. injections of 0·7 µg E2/mouse or 75 µg estren/mouse during 4 weeks. Control mice received vehicle olive oil. Treatment with E2 or estren resulted in inhibited serum levels of IL-6 in WT mice but not in DERKO mice. One-way anova followed by Fisher's exact test was used to compare data from control mice with E2- or estren-treated mice. **P < 0·01. Results are presented as mean ± standard deviation. n = 5–8 mice in each group.