Table 1.
Patients’ characteristics and analysis of CD4 and CD8 T cell subsets.
| dSSc (n = 11) | lSSc (n = 11) | RP (n = 10) | Ctrl (n = 11) | |
|---|---|---|---|---|
| Age (years)(mean ± SEM) | 48 ± 4 | 54 ± 2 | 46 ± 3 | 52 ± 2 |
| Sex ratio (female/male) | 10/1 | 8/3 | 7/3 | 9/2 |
| Duration of the disease (mean ± SEM; years) | 7 ± 1·6 | 8 ± 1·3 | – | – |
| Total lymphocyte counts (109/l) | 42 ± 7 | 55 ± 9 | 44 ± 4 | 47 ± 6 |
| CD4+ (% ± SEM) | 48 ± 2 | 52 ± 2 | 38 ± 4 | 45 ± 2 |
| CD8+ (% ± SEM) | 19 ± 2* | 24 ± 2 | 27 ± 3 | 29 ± 2 |
| CD4+ HLA-DR+ (% ± SEM) | 3 ± 1 | 3 ± 1 | 4 ± 1 | 3 ± 1 |
| CD4+ CD25+ (% ± SEM) | 2 ± 1 | 4 ± 1 | 5 ± 1 | 3 ± 1 |
| CD8+ HLA-DR+ (% ± SEM) | 4 ± 1 | 5 ± 1 | 5 ± 1 | 5 ± 1 |
| CD8+ CD25+ (% ± SEM) | 2 ± 2 | 1 ± 0·3 | 1 ± 1 | 0 ± 0·3 |
dSSc, diffuse systemic sclerosis; lSSc, limited systemic sclerosis; RP, primary Raynaud's phenomenon: Ctrl, controls (healthy volunteers).
*
P < 0·05 as compared to Ctrl (Mann–Whitney test).