Fig. 2.
Effect of low-dose VIP infusion in TNBS-induced mice. TNBS-challenged mice were administered a constant infusion of VIP from day 4 (5 × 10−5m) (therapeutic mode) or day 0 (1 × 10−4m) (prophylactic mode) post-induction of colitis with euthanasia at day 7. (a) Clinical score from 3-day VIP-infused mice and (b) weight changes of 3- and 7-day VIP-infused animals were assessed. Weight changes expressed as percentage of original weight from day 0. Each point represents mean ± s.d. from five to 10 mice.