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. 2005 Apr;140(1):54–64. doi: 10.1111/j.1365-2249.2005.02730.x

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Fig. 6 — Trypsin or DNase digestion of necrotic K562 cells reduced secretion of IL-12p40 by DCs. Monocyte-derived DCs were cultured with killed K562 cells, trypsin-digested (a) or DNase-digested (b) killed cells. Error bars represent duplicates of culture. In five experiments with different donors, trypsin-digestion of particulate fractions of injured cells significantly reduced IL-12p40 secretion (for heat-killed K562 cells P = 0·028, for freeze/thaw-killed K562 cells P = 0·043). DNase-digestion significantly reduced IL-12p40 secretion only with freeze/thaw-killed K562 cells (P = 0·04) but not with heat-killed cells (P = 0·06).