Table 1.

The effect of periodical administration of anti-MAdCAM-1 and anti-VCAM-1 on the development of ileitis in SAMP1/Yit mice. Villus height, submucosal thickness, and the number of cells expressing CD4, CD8 and β7-integrin in lamina propria after 7-week treatment in each groups (The prevention study).

	Control IgG	Anti-MAdCAM-1	Anti-VCAM-1
Villus height (µm)	110 ± 18	187 ± 31*	107 ± 35
Submucosal thickness (µm)	85·0 ± 12·9	51·3 ± 27·8	64·5 ± 24·0
CD4	357 ± 51	170 ± 34*	324 ± 67
CD8	285 ± 44	141 ± 23*	197 ± 84
β7-integrin	190 ± 20	74 ± 20*	178 ± 86

The infiltrating cells were expressed as the numbers of CD4, CD8 and β7-integrin-positive cells per millimeter of muscularis mucosa. All results were expressed as means ± SE of 4 mice.

^*P < 0·05 versus Control IgG.