Table 2.

Effect of periodical administration of anti-MAdCAM-1 or control IgG on established ileitis of SAMP1/Yit mice age of 28 weeks. Villus height, submucosal thickness, and the number of cells expressing CD4, CD8 and β7-integrin in lamina propria after 7-week treatment in each groups (The treatment study).

	Control IgG	Anti-MAdCAM-1
Villus height (µm)	93 ± 27	143 ± 29*
Submucosal thickness (µm)	105 ± 26	76 ± 16
CD4	287 ± 44	190 ± 34*
CD8	246 ± 39	168 ± 28*
β7-integrin	168 ± 38	81 ± 16*

The infiltrating cells were expressed as the numbers of CD4, CD8, and β7-integrin-positive cells per millimeter of muscularis mucosa. All results were expressed as means ± SE of 4 mice.

^*P < 0·05 versus Control IgG.