(a,b) Serum concentrations of anti-α-fodrin IgA and IgG autoantibodies. Cut-off values for IgA and IgG are shown as horizontal lines. GD: Graves' disease without manifest ophthalmopathy; GO: Graves' ophthalmopathy; RA: rheumatoid arthritis; Crohn: Crohn disease; HT: Hashimoto thyroiditis; SLE: systemic lupus erythematosus. Significant differences versus patients with GO for IgA: GD, P < 0·001; HT, P < 0·001; RA, P < 0·001; Crohn, P = 0·003 (Mann–Whitney U-tests). For IgG: GD, P < 0·001; HT, P < 0·001; RA, P < 0·001; Crohn, P < 0·001; SLE, P = 0·001.