Fig. 2.

(a) The disease activity index (DAI) in macrophage migration inhibitory factor (MIF) transgenic (Tg) mice was significantly higher than that in wild-type (WT) mice during the 1% dextran sulphate sodium (DSS) treatment. DAI was assessed daily during the 1% DSS treatment as described in Materials and methods. (b) Survival rate during DSS-induced colitis. Four per cent DSS in the drinking water was given to MIF Tg mice (n = 10) and WT mice (n = 10). Survival was recorded daily. All data are presented as the mean ± s.e. Statistical significance was assessed compared with WT mice on the same day. *P < 0·05, **P < 0·001.