Fig. 7.
Inhibitory effect of LcS (a) or the cellular components of LcS (b) on the production of IL-6 in LPS-stimulated PBMC isolated from patients with ulcerative colitis. (a) PBMC isolated from 10 patients with UC were stimulated with LPS in the absence or presence of LcS (2·5 µg/ml). (b) Inhibitory effects of LcS or LcS-derived cellular components on the production of IL-6 in LPS-stimulated PBMC isolated from patients with ulcerative colitis. PBMC isolated from UC patients were stimulated with LPS in the absence or presence of various doses of the cell components. After 48 h culture, amounts of IL-6 in the culture supernatants were determined by sandwich ELISA. Data represent the percent inhibition of IL-6 synthesis in the cultures stimulated with LPS plus LcS components compared with those stimulated with LPS only. Data represent mean ± SD.