Table 2.
Median (range) titres of pneumococcal antibodies in patients with ataxia–telangiectasia and controls
| A-T patients | Controls | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Pneumococcal serotype | Unit | Preimmunization n =12 | Postimmunization n = 9 | P-value | Fold increase‡ | Preimmunization n = 25 | Postimmunization n = 25 | P-value | Fold increase‡ |
| Serotype 4 | µg/ml | 0·1 (0·05–0·2) | 0·7 (0·1–4·6) | 0·014* | 7·0 | 0·3 (0·1–14·7) | 8·1 (2·0–48·4) | 0·001* | 27 |
| Serotype 6B | µg/ml | 0·2 (0·1–1·2) | 0·3 (0·1–1·0) | 0·506 | 1·5 | 0·7 (0·2–11·8) | 6·2 (0·3–190·3) | 0·001* | 8·9 |
| Serotype 14 | µg/ml | 0·3 (0·1–0·7) | 0·9 (0·1–13·0) | 0·037* | 3·0 | 0·65 (0·05–3·9) | 22 (3·4–92·7) | 0·001* | 33·9 |
| Serotype 18C | µg/ml | 0·1 (0·05–0·2) | 0·3 (0·1–3·4) | 0·059 | 3·0 | 0·8 (0·1–15·6) | 9·0 (1·5–20·1) | 0·001* | 11·3 |
| Serotype 19F | µg/ml | 0·25 (0·1–0·6) | 0·5 (0·2–1·2) | 0·009* | 2·0 | 1·2 (0·2–33·5) | 18·4 (0·4–75·8) | 0·001* | 15·3 |
| Serotype 23F | µg/ml | 0·2 (0·05–5·5) | 0·3 (0·1–7·9) | 0·430 | 1·5 | 0·9 (0·2–11·6) | 9·6 (0·9–183·8) | 0·001* | 10·7 |
| Geom.mean | µg/ml | 0·2 (0·1–0·5) | 0·6 (0·2–1·5) | 0·014* | 3 | 0·7 (0·2–9·8) | 10·3 (1·9–51·5) | 0·001* | 14·7 |
| PPV23 mix | U/ml | 0·65 (0·2–3·6) | 5·7 (1·0–28·3) | 0·001* | 8·8 | 3·8 (0·4–109·4) | 36·7 (8–292·6) | 0·001* | 9·7 |
*
Significant differences between pre- and postimmunization;
‡
Fold increases are calculated from the median values.