Fig. 2.

Modulation of IL-1β and IL-1receptor antagonist by serum IgA (10 mg/ml). The results are arithmetic means from triplicate cultures ± SD (n = 3) stimulated for 24 h (representative results from one blood donor). Monocytes and PBMC were stimulated with LPS alone (, or with LPS in the presence of serum IgA; Lot 582 () or Lot 593 (). To estimate the influence of IgA on resting monocytes or on resting PBMC the cells were incubated with IgA alone: Lot 582 () or Lot 593 (▪). Control cells were cultured in medium (Med) alone (□). Statistically significant difference between either IgA-treated versus control cultures or IgA + LPS-treated versus LPS alone denoted as: *P < 0·05, **P < 0·01, ***P < 0·001.