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. 2005 Jul;141(1):89–98. doi: 10.1111/j.1365-2249.2005.02820.x

Table 1. Characteristics of patients with chronic and subacute neuroborreliosis.

No. Age Sex Diagnosis Disease course Symptoms Duration of symptoms Borrelia IgG serum (±) Borrelia IgM serum (±) CSF-IgG Borrelia antibody indexa (±) CSF-IgM Borrelia antibody indexa (±) CSF-MNC- pleocytosisb (±) CSF- albumin quotientc (±) CSF-IgG synthesis indexd (±) CSF- oligo- clonal bands (±)
1 46 F NB Chronic Back- and neck pain, headache, cognitive impairment 5 years + + + + + + + +
2 83 F NB Chronic Memory deficit, numbness, muscle weakness right arm, nausea, vertigo 6 months + − + − + − + +
3 70 M NB Chronic Radiculitis, paresthesia, numbness, thoracic neuralgia 11 months + + + − + + + +
4 71 M NB Chronic Radiculitis, arthritis, headache, neck stiffness 5 years + − + − − − + +
5 77 M ACA Chronic Headache, vertigo, radiculitis 4 years + − − − − + − −
6 37 M NB Chronic Arthralgia, neck- and back pain, headache, paresthesia 3 years + + + − + − − n.d.
7 68 M NB Chronic Headache, radiculitis, facial palsy, fatigue, vertigo 10 months n.d. n.d. + − + + − n.d.
8 50 M NB Subacute Tremor, vertigo, myalgia, radiculitis, back pain 2 months − + + + + + + −
9 25 M NB Subacute Headache, facial palsy 2 months + + + + + + + n.d.
10 46 M NB Subacute Facial palsy, memory deficits, numbness, hypoesthesia 5 months + + + + + n.d. n.d. n.d.
11 55 M NB Subacute Facial palsy, diplopia 1·5 months + + + + + + + +
12 67 M NB Subacute Facial palsy, headache, radiculitis, numbness 1 month + + + + + + + n.d.
13 49 M NB Subacute Headache, weight loss, fatigue, eye dazzle 2 months − − + + + + + n.d.
14 67 F NB Subacute Arthralgia, facial palsy, radiculitis, nausea 5 months − − − + + + − +

NB, neuroborreliosis; ACA, acrodermatitis chronicum atrophicans; chronic > 6 months’ duration; subacute < 6 months’ duration; CSF, cerebrospinal fluid; MNC, mononuclear cell; n.d., not done.

a

Borrelia-specific CSF antibody index was defined according to Hansen and Lebech, 1991.

b

Mononuclear pleocytosis in CSF was defined as positive if ≥ 5·0 × 106 mononuclear cells/l.

c

CSF albumin quotient was defined as positive if > 8·1 × 103.

d

IgG synthesis index in CSF was defined as positive if >1·25.