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Role of T-cells in granuloma formation in in vitro and in vivo models.
| Model | Main findings | Reference |
|---|---|---|
| In vitro granuloma model | • Activated T-cells induce necrotic centres in granulomatous lesions | [97] |
| In vivo granuloma model | • Activated CD4 Th1-type cells induce the transformation from an unspecific microabscess to granuloma formation | [98] |
| •T-cells and IFN-γ are crucial in granuloma formation | [99] |
