Table 2b. Peripheral blood mononuclear cells (PBMC), interferon (IFN)-γ and interleukin (IL)-10 responses to VP1/2, VP2 and to tetanus toxoid (TT) among recently (C1–9) and remotely (S1–23) parvovirus B19 infected subjects compared with responses among non-immune (Ni1–16) subjects.
| Δ CPMa (pg/ml) ± s.d. | Δ CPMb (pg/ml) ± s.d. | |||||
|---|---|---|---|---|---|---|
| Subjects | VP1/2 | VP2 | TT | VP1/2 | VP2 | TT |
| C1-9 | 568 ± 456 | 499 ± 473 | 101 ± 211 | 50 ± 44 | 55 ± 65 | 14 ± 23 |
| S1-23 | 138 ± 210 | 164 ± 239 | 158 ± 200 | 35 ± 28 | 34 ± 29 | 74 ± 63 |
| Ni 1–16 | 0 | 1 ± 3 | 188 ± 25 975 | 4 ± 6 | 5 ± 7 | 82 ± 73 |
a
IFN-γ measured from tissue culture supernatant.
b
IL-10 measured from tissue culture supernatant. Background cytokine production was subtracted from total to yield antigen-specific cytokine production. Background IFN-γ responses ranged 0–0, 0–26 (mean 3) and 0–12 (mean 2) pg/ml among recently and remotely infected and seronegative subjects, respectively, and the corresponding background IL-10 responses ranges were 0–40 (mean 14), 0–22 (mean 7) and 0–27 (mean 9) pg/ml, respectively.