Table 2.
.Cytokine production by HIV peptide-specific CD8+ T cells in chronic individuals.
| Patient no. | Laboratory ID | CDC stage | Peptide no. | Region of protein | Amino acid sequence | Parental protein | CD69+ IL-2+ (%) | CD69+ IFN-γ+ (%) |
|---|---|---|---|---|---|---|---|---|
| 1 | 111000 | A1 | 67–68 | Gag264–274 | PVGDIYKRWII | p24 | < 0·01 | 0·2 |
| 2 | 111181 | A1 | 89–90 | Gag347–357 | EEMMTACQGVG | p24 | < 0·01 | 0·18 |
| 3 | 111188 | A1 | 20–21 | Gag82–92 | SLFNTVATLY | p17 | < 0·01 | 0·3 |
| 22–23 | Gag92–103 | YCVHAGIEVRD | p17 | < 0·01 | 0·51 | |||
| 55–56 | Gag216–226 | AAEWDRLHPVH | p24 | < 0·01 | 0·56 | |||
| 109–110 | Gag426–436 | DCTERQANFLG | p15 | < 0·01 | 0·1 | |||
| 4 | 111231 | A1 | 79–80 | Gag308–318 | RAEQATQDVKN | p24 | < 0·01 | 0·41 |
| 5 | 111054 | A2 | 46–47 | Gag176–186 | ALSEGATPQDL | p24 | < 0·01 | 1·13 |
| 6 | 111118 | A2 | 51–52 | Gag195–205 | GGHQAAMQMLKD | p24 | < 0·01 | 0·11 |
| 7 | 111154 | A2 | 5, 6 | Gag25–35 | RLRPGGKKHYM | p17 | < 0·01 | 0·2 |
| 33–34 | Gag133–143 | GKKVSQNYPIV | p17–p24 | < 0·01 | 0·45 | |||
| 8 | 111190 | A2 | 20–21 | Gag82–92 | SLFNTVATLY | p17 | < 0·01 | 0·25 |
| 70–71 | Gag275–285 | LGLNKIVRMYS | p24 | < 0·01 | 0·1 | |||
| 9 | 111221 | A2 | 5, 6 | Gag25–35 | RLRPGGKKHYM | p17 | < 0·01 | 0·1 |
| 7, 8 | Gag33–43 | HYMLKHLVWAS | p17 | < 0·01 | 0·1 | |||
| 33–34 | Gag133–143 | GKKVSQNYPIV | p17–p24 | < 0·01 | 0·14 | |||
| 99–100 | Gag386–396 | SKRIVKCFNCG | p15 | < 0·01 | 0·15 | |||
| 10 | 111246 | A2 | 49–51 | Gag188–201 | NTMLNTVGGHQAAM | p24 | < 0·01 | 0·16 |
| 11 | 111288 | A2 | 43–44 | Gag171–181 | AFSPEVIPMFT | p24 | < 0·01 | 1·49 |
| 12 | 111296 | A2 | 124–125 | Gag486–496 | PLTSLKSLFGS | p15 | < 0·01 | 0·11 |
| 13 | 111053 | B1 | 22–23 | Gag93–103 | YCVHAGIEVRD | p17 | < 0·01 | 0·13 |
| 109–110 | Gag426–436 | DCTERQANFLG | p15 | < 0·01 | 0·19 | |||
| 124–125 | Gag486–496 | PLTSLKSLFGS | p15 | < 0·01 | 0·14 | |||
| 14 | 111102 | B1 | 21–22 | Gag87–97 | VATLYCVHAGI | p17 | < 0·01 | 0·3 |
| 45–46 | Gag178–188 | PMFTALSEGAT | p24 | < 0·01 | 0·17 | |||
| 15 | 111104 | B1 | 5, 6 | Gag25–35 | RLRPGGKKHYM | p17 | < 0·01 | 0·18 |
| 103–104 | Gag402–412 | IAKNCRAPRKK | p15 | < 0·01 | 0·14 | |||
| 16 | 111434 | B1 | 51–52 | Gag195–205 | GGHQAAMQMLK | p24 | < 0·01 | 0·24 |
| 17 | 111002 | B2 | 55–56 | Gag212–222 | AAEWDRLHPVH | p24 | < 0·01 | 0·64 |
| 87–88 | Gag343–353 | ALGPGASLEEM | p24 | < 0·01 | 0·6 | |||
| 18 | 111086 | B2 | 99–100 | Gag386–396 | SKRIVKCFNCG | p15 | < 0·01 | 0·14 |
| 109–110 | Gag426–436 | DCTERQANFLG | p15 | < 0·01 | 0·15 | |||
| 124–125 | Gag486–496 | PLTSLKSLFGS | p15 | < 0·01 | 0·11 | |||
| 19 | 111428 | B3 | 79–80 | Gag308–318 | RAEQATQDVKN | p24 | < 0·01 | 0·12 |
| 87–88 | Gag343–353 | ALGPGASLEEM | p24 | < 0·01 | 0·14 | |||
| 20 | 111440 | B3 | 1, 2 | Gag5–15 | ASILRGGKLDK | p17 | < 0·01 | 0·11 |
| 21 | 110976 | C2 | 56–57 | Gag217–227 | RLHPVHAGPIA | p24 | < 0·01 | 0·45 |
| 59–60 | Gag229–239 | GQMREPRGSDIA | p24 | < 0·01 | 0·2 | |||
| 110–111 | Gag429–439 | ERQANFLGKIW | p15 | < 0·01 | 0·4 | |||
| 22 | 111052 | C2 | 70–71 | Gag275–285 | LGLNKIVRMYS | p24 | < 0·01 | 0·15 |
| 23 | 110977 | C3 | 45–46 | Gag178–188 | PMFTALSEGAT | p24 | < 0·01 | 0·12 |
| 24 | 110983 | C3 | 59–60 | Gag229–239 | GQMREPRGSDIA | p24 | < 0·01 | 0·17 |
| 25 | 111292 | C3 | 56–57 | Gag217–227 | RLHPVHAGPIA | p24 | < 0·01 | 0·15 |