Table 3.

Summary of frequently recognized peptides in the study cohort.

Peptide no.	Region of protein	Amino acid sequence	Subtype B epitopes in subtype C peptide sequence	Parental protein	Study subjects with response (%)
CD8+ T cell responses
5, 6	Gag20–30	RLRPGGKKHYM	WEKIRLRPGGKKKYK, KIRLPGGK, KIRLPGGKKKYKLIRLRPGGKK, RLRPGGKKKY	p17	12%
20–23	Gag78–96	SLFNTVATLYCVHAGIEVRD	RSLYNTVATLY, SLYNTVATL, NTVATLYCV, TLYCVHQR, TLYCVHQRI, YCVHQRIEIKDTKEAL	p17	16%
33–34	Gag128–138	GKKVSQNYPIV	QVSQNYPIV, NYPIVQNL	p17–p24	8%
45–46	Gag173–183	PMFTALSEGAT	AFSPEVIPMFSALSEGATPQ, EVIPMFASALSEGATP, IPMFSALSEGATPQDL	p24	8%
51–52	Gag196–206	GGHQAAMQMLKD	GHQAAMQMLKE	p24	8%
55–57	Gag212–227	AAEWDRLHPVHAGPIA	LKETINEEAAEWDRVHPV, AEWDRVHPV, VHPVHAGPIA, HPVHAGPIA	p24	16%
59–60	Gag229–240	GQMREPRGSDIA	HAGPIAPGQMREPRG, IAPGQMREPRGSDIAGTTST	p24	8%
70–71	Gag271–281	LGLNKIVRMYS	IYKLWIILGLNKIVRMYSPT, KRWIILGLNKIVRMYSPTSI	p24	8%
79–80	Gag308–318	RAEQATQDVKN	FKTLRAEQATQDVKNWMTDT	p24	8%
87–88	Gag339–349	ALGPGASLEEM	KTILRALGPGATLEEMMTAC	p24	8%
99–100	Gag387–397	SKRIVKCFNCG	SNFKGNKRMVKCFNCGKEGH	p15	8%
109–111	Gag426–439	DCTERQANFLGKIW	KEGHQMKDCTERQANF, CTERQANFL, TERQANFL, RQANFLGKIWPSYKG, CTERQANFL, FLGKIWPS	p15	16%
124–125	Gag483–493	PLTSLKSLFGS	KELYPLTSL, TPLSTLRSLF	p15	12%
CD4+ T cell responses
43–46	Gag166–183	AFSPEVIPMFTALSEGAT	AFSPEVIPMFSALSEC	p24	8%
62–63	Gag241–251	GTTSTLQEQIA	GSDIAGTTSTLQEQIC	p24	8%
64–66	Gag248–262	EQIAWMTSNPPVPVG	STLQEQIGWMTNNPPIPVGE	p24	8%