Fig. 3.

Leucocyte extravasation is still markedly increased 4 weeks after the last cycle of dextran sodium sulphate (DSS) in chronic colitis compared to control animals (n = 6/group; median and range, #P < 0·01 versus healthy control). Application of anti-CD44 variant isoform 7 (CD44v7) antibody significantly down-regulates leucocyte extravasation compared to animals which were treated with an isotype-matched antibody or anti-CD44v4 antibody (*P < 0·01 versus isotype antibody and anti-CD44v4 antibody).