Table 3. Human leucocyte antigen (HLA)-DR binding capacity of each paramyosin peptide selected by TEPITOPE.
Binding capacity (IC 50 nM) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Sequence | Position | DR1 DRB1*0101 | DR4w4 DRB1*0401 | DR4w15 DRB1*0405 | DR7 DRB1*0701 | DR5w11 DRB1*1101 | DR6w19 DRB1*1302 | DR2w2 B1 DRB1*1501 | DRw2B2 DRB5*0101 | Molecules bound |
TESHVKISRTIYRGVSP | 6–22 | 870 | 3739 | 2399 | 288 | 198 | 457 | 387 | 28 | 6 |
SRTIYRGVSPSTTRLES | 13–29 | 7·5 | 437 | 86 | 53 | 737 | 596 | 334 | 43 | 8 |
LDGALKAKQSAESKLEG | 151–167 | 1406 | 6055 | 22267 | 21959 | 3039 | 23034 | 884 | 412 | 2 |
LDSQLNRLKSLTDDLQR | 168–184 | 1280 | 34 | 14 | 8824 | 1985 | 9529 | 5599 | 314 | 3 |
YEAQILNYSKAKSSLES | 210–226 | 49 | 861 | 12 | 10 | 23 | 255 | 42 | 28 | 8 |
NSELIRRAKAAESLASD | 355–371 | 4·4 | 11 | 820 | 377 | 75 | 279 | 151 | 19 | 8 |
RLKSLVNDLTDKNNLLE | 399–415 | 294 | 784 | 2630 | – | – | 84 | – | – | 3 |
AENNLQITEHKRLQLAN | 584–600 | 1780 | – | – | 30 | 43 | 3721 | 59 | 18110 | 3 |
NNEVLRLADELRQEQGN | 676–692 | 2804 | 7690 | 24506 | – | 4940 | – | 42159 | 1079 | 0 |
FERQYKELQTQAEDDRR | 760–776 | 7·4 | 305 | 16 | 22380 | 89 | – | 5401 | 3098 | 4 |
AERTVTVRRVGPGGRAV | 830–846 | 7·7 | – | – | 7855 | 9153 | – | 27 | 2·4 | 3 |
Significant affinity threshold < 1000, shown in bold type. Dash (–) means IC50% > 30 000.